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PMPC only updates the EXE version I think, since the MSI version is developed for companies, which may deploy software through Active Directory, which only supports MSI.

PMPC has a build in scheduler, so you can schedule the run at a time where your mom is normally logged on.
In addition the task is run if a run is missed.

As far as I can tell portable applications are not scanned, they are just downloaded.
I have never used that feature, just made a simple test, where only the ZIP file was downloaded.

There is a context menu for all applications listed, see image below.

Seems that one was installed with the MSI installer and one with the EXE.
Remove both and install with PMPC.

Initially any application that PMPC knows will be updated.
If you do not want to update a specific application, you can select to exclude it from scanning.

See https://ideas.patchmypc.com/ if it is already requested and if not request it.

Sometimes the old release of a program must be removed manually.

In general PMPC is just the executable.
So if you have a copy of the old EXE just replace the new EXE.
Just make sure to disable the auto update.

I did not meant to search in the log file, I meant to search the whole internet.

Have you searched the web for "Cortex XDR Agent error 0x80004005"?
The results should lead you to a solution.

Use the uninstaller section to remove the old versions.
In rare cases an update is not possible and you need to remove the old release before installing the new one.
Once this is done the automatic update works as expected.

Yes, the 2015-2022 package replaces the 2015-2019 package.

I do not know how PMPC gets the desktop folder, through API or registry.
You can specify the folder for the portable apps through the context menu of the group in the PMPC window.
See https://patchmypc.com/forum/index.php?topic=4907.msg12703#msg12703

If you have not set it then it is included as an information in the log file.